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Table 1 Databases and resources useful for researching PPIs.

From: Construction and analysis of protein–protein interaction networks

Database URL Resources Refs.
BIND Peer-reviewed bio-molecular interaction database containing published interactions and complexes http://bind.ca/ [79]
BioGRID Protein and genetic interactions from major model organism species http://www.thebiogrid.org/ [80]
COGs Orthology data and phylogenetic profiles http://www.ncbi.nlm.nih.gov/COG/ [81, 82]
DIP Experimentally determined interactions between proteins http://dip.doe-mbi.ucla.edu/ [51]
HPRD Human protein functions, PPIs, post-translational modifications, enzyme–substrate relationships and disease associations http://www.hprd.org/ [50, 83]
IntAct Interaction data abstracted from literature or from direct data depositions by expert curators http://www.ebi.ac.uk/intact/ [84]
iPFAM Physical interactions between those Pfam domains that have a representative structure in the Protein DataBank (PDB) http://ipfam.sanger.ac.uk/ [85]
MINT Experimentally verified PPI mined from the scientific literature by expert curators http://mint.bio.uniroma2.it/mint/ [86]
Predictome Experimentally derived and computationally predicted functional linkages http://visant.bu.edu/ [52]
ProLinks Protein functional linkages http://mysql5.mbi.ucla.edu/cgi-bin/functionator/pronav [87]
SCOPPI Domain–domain interactions and their interfaces derived from PDB structure files and SCOP domain definitions http://www.scoppi.org/ [88]
STRING Protein functional linkages from experimental data and computational predicttions http://string.embl.de/ [36, 48]